Summarization of CBD and Brain Function

Here is a great study on CBD and brain function https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858248/

Below are the summarized points:

• Cannabidiol (CBD) may have antipsychotic and anxiolytic properties.
• The neurobiological substrates underlying the therapeutic effects of CBD are still unclear.
• Neuroimaging studies have shown that acute CBD alters brain activity and connectivity patterns.
• CBD enhances fronto-striatal resting state connectivity in healthy volunteers.
• CBD modulates brain activity during various cognitive tasks, such as emotional processing, verbal memory, response inhibition, and auditory/visual processing.
• Acute CBD shows intermediate brain activity in individuals at clinical high risk for psychosis and patients with established psychosis.
• CBD modulates resting limbic activity in subjects with anxiety and metabolite levels in patients with autism spectrum disorders.
• Future studies should replicate findings and include larger samples of psychiatric patients.
• CBD affects brain function in various regions, including the cingulate cortex, precuneus, cuneus, inferior frontal gyrus, middle frontal gyrus, insula, putamen, precentral gyri, fusiform gyrus, cerebellum, lingual gyrus, and thalamus.
• CBD can increase or decrease blood flow in different brain regions, such as the parahippocampal gyrus/hippocampus and posterior cingulate cortex.
• CBD enhances fronto-striatal connectivity and decreases limbic activity during resting state.
• CBD modulates brain activity during different cognitive tasks, including response inhibition, auditory processing, verbal learning, emotional processing, and visual and auditory processing.
• CBD has different effects compared to THC on brain function in healthy volunteers.
• CBD increases connectivity between the right putamen and frontal pole and paracingulate gyrus.
• Cannabis containing both THC and CBD increases connectivity in the salience network compared to cannabis without CBD.
• Cannabis without CBD dampens the response to music in the auditory cortex, hippocampus, ventral striatum, and amygdala.
• The right ventral striatum shows increased functional connectivity with the bilateral auditory cortex during music perception.

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